Dr. Mahmoud Farouk

mfa23@yahoo.com  

Heterocyclic chemistry, attracts great attention from organic chemists, comprises at least half of all organic chemistry research worldwide. In particular, heterocyclic structures from the base of many pharmaceutical, veterinary, and agriculture products1. 3-Substituted quinazolinedions2 I are classes of fused heterocycles that are of considerable interest because of the diverse range of their biological properties3. Many active organic compounds are poorly soluble in water, or even insoluble3,4. The most interesting properties of nanodispersions of active organic compounds include the notable increase in solubility, the improvement in biological resorption, and other chemical and physical properties which are achievable only with particle sizes in the middle or lower nanometer range. The development of new processes for the production of organic nanoparticles as alternatives to the established classical organic compounds give the hope for the delivery of drugs that exhibit the problems of short half-life, poor bioavailability, strong side effects, insolubility and instability in biological environment2,3.

1) Tetrahedron 60, 10153-10202, 2005.

2) M. A. Hassan, S. E. Zayed, M. Farouk, New 3-Substituted Quinazolinediones, Part 1.One-pot Synthesis Of 3- Subsituted Quinazoline-2,4-dione Derivatives, under publication, 2009.