Angstrom-Technology: Detection of proteins on cancer cells could play a role in the methods of therapy

^1,3Al-ani Ma’an N.R.,² Biggerstaff J,. ⁴Al-Thani K.J, ¹Richardson  M.

¹University of Central Florida, College of Optics and Photonics, Orlando, Fl 32816 USA

²University of Tennessee, Biological Imaging Unit, Tn, USA

³LXRYM Opto Technology Inc., 9515 Woodbreeze, Blvd., Windermere, Fl 34786 USA

⁴Qatar National Cancer Society P.O Box 22944

E-mail: Dr. Ma'an Al-Ani at: maan.alani@gmail.com

ABSTRACT

The development of x-rays induced by a nano-pulse laser allows us to visualize proteins and sub-cells of less than 800 angstrom-structure (10^-12 m = 1?) atomic size, with sufficient temporal and spatial resolution and with a level of specificity so that we can understand their structural and functional dynamics (Figure 1).

Cancer therapies today, although often effective, are invasive and difficult for the patient too undergo.   Preventative strategies and therapies are the focus of current research and study in this field. Stem cells are primal cells common to all multi-cellular organisms. They retain the ability to renew themselves through cell division, and can differentiate into a wide range of specialized cell types such as breast, lung, etc.  Identification of proteins on breast cancer cells, which contribute to the abnormality of immune-system and stem cells, may provide us with new strategies to prevent deadly diseases. In our previous studies on the role of the coagulant system in cancer growth and spread, we identified some proteins that paralyzed the immune system parameters (1, 2). We believe that the cancerous stem cells spread (1, 3, 4), some of which have been seen in the lung (4, 5). Therefore, the stem cell could be a precursor for lung cancer.

The goal of these studies is continue the development of x-ray imaging in real-time and with high resolution. X-ray radiography, using nano-pulse lasers, allows researchers to see the interaction between proteins and cancer cells.  Therefore, these studies may expedite the finding of tests or drugs that have a potential to save lives and reduce patients' exposure to the toxic side effects of chemotherapy.

Keywords: Breast cancer, Coagulant, Nano-laser, Stem cells, X-ray.

Dr. Ma’an N.R AL-Ani: Research Center and Education in Optics and Lasers (CREOL),

Orlando, Fl 32816 USA / Phone # +1 561 625 9947

E-Mail: maan.alani@gmail.com

References:

1. Al-ani Ma’an N.R.,  Biggerstaff J. Richardson M., and Al-Thani, K.J, Nano-structure Studies of Living Cells: The Role of the Coagulation System in Cancer Growth and Spread, Int. J. Sci. Res., Vol. 16 (2006), pp. 371-375.

2. AL-Ani Ma’an N.R, X-ray Microscopy of Live Biological Micro-Organisms, USA Copyright Office, the Library of Congress # TX 5-479-332 February 27, 2002. ?

3. Smalley M., Ashworth A., Stem cells and breast cancer: A field in transit. Nat Rev Cancer 2003, 3:832-84.

4. Chepko G, Smith GH: Mammary epithelial stem cells: our current understanding. J Mammary Gland Biol Neoplasia 1999, 4:35-52.

5. Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT, Jacks T. Identification of bronchioalveolar stem cells in normal lung and lung cancer, Cell. 2005 Jun 17;121 (6):811-3.

Figure1: X-ray radiography showing lung cells contaminated with cancerous stem cells images.