1Department of Pharmaceutics, Faculty of Pharmacy,

King Saud University, Riyadh,  Saudi Arabia. 

2Al-Azhar University, Faculty of Pharmacy,  Nasr City, Cairo, Egypt.

In the present study, a new self-nanoemulsified drug delivery formulation (SNEDDF) of indomethacin (IND) was tested in rats for its in vivo performance. Pharmacokinetic studies of IND SNEDDF was carried out after oral administration of the prepared formulation (capsules) and compared with that of orally administered IND oily solution. From the pharmacokinetic parameters, it was found that IND SNEDD capsules have improved bioavailability over IND oily solusion capsules. The values of AUC and Cmax for IND SNEDD capsule were 792.17 ± 68.44 ng.hr/ml and 130.45 ± 4.84 ng/ml respectively as compared to 151.50 ± 33.14 ng.hr/ml and 23.83 ± 3.66 ng/ml for IND oily solution capsules. The study showed that SNEDDF could be used not only to enhance the bioavailability of lipophilic drugs but also to decrease the regular doses of these drugs, which may lead to eliminate or reduce their side effects as well.

 

*Corresponding author

Ehab I. Taha, Ph. D.

Department of Pharmaceutics, Faculty of Pharmacy

King Saud University

PO Box 2457  Riyadh 11451

Kingdom of Saudi Asabia

Tel: 00966-567843885 

Fax: 00966-14676295

E-mail: ehab71328@yahoo.com  , eelbadawi@ksu.edu.sa